The

rule of threestates that if a certain event did not occur in a sample withnsubjects, the interval from 0 to 3/nis a 95% confidence interval for the rate of occurrences in the population. Whennis greater than 30, this is a good approximation of results from more sensitive tests.

Source: https://en.wikipedia.org/wiki/Rule_of_three_(statistics)

A citation for this is Ernst, et al., 1995.

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